The TY/23 monoclonal antibody reacts with mouse CD73 also known as ecto-5'-nucleotidase (5'-NT), a 69 kDa GPI-anchored cell-surface protein. In mice, expression of CD73 is restricted to CD11b+ myeloid cells in the bone marrow and T cells in the spleen. CD73 plays a strategic role in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of AMP to adenosine. This drives a shift from an ATP-driven proinflammatory environment to an anti-inflammatory milieu induced by adenosine. CD73 has been shown to be important for the immunosuppressive activity of regulatory T cells. The TY/23 antibody has been reported to inhibit the enzymatic activity of CD73.

產(chǎn)品名稱(chēng):InVivoMab anti-mouse CD73

反應(yīng)種屬:mouse

宿主來(lái)源:rat

實(shí)驗(yàn)應(yīng)用:in vivo CD73 blockade

同種型:IgG2a, κ

免疫原:BALB/c mouse spleen cells and CHO cells transfected with the mouse CD73 gene

克隆性:Monoclonal

克隆號(hào):TY/23

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國(guó)

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